Blar i forfatter "Skjefstad, Kaja Konstanse"

Viser treff 1-4 av 4

    • A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer 

      Skjefstad, Kaja Konstanse; Johannessen, Charles; Grindstad, Thea K.W.; Kilvær, Thomas Karsten; Paulsen, Erna Elise; Pedersen, Mona Irene; Dønnem, Tom; Andersen, Sigve; Bremnes, Roy M.; Richardsen, Elin; Al-Saad, Samer; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-04)
      Micro RNAs (miRNA) are small non-coding RNAs that post-transcriptionally regulate gene expression. Dysregulation of miRNA cluster 143/145 has been reported in several malignancies, but their role in non-small cell lung cancer (NSCLC) remains elusive. This study investigates the prognostic impact of miR-143 and miR-145 in primary tumors and metastatic lymph nodes in NSCLC tissue. Tissue from 553 ...

    • The prevalence and prognostic significance of endocrinology-related biomarkers in non-small cell lung cancer 

      Skjefstad, Kaja Konstanse (Doctoral thesis; Doktorgradsavhandling, 2018-06-22)
      Lung cancer has become a global health issue, and accounts for over 1.6 million annual deaths worldwide. The need for an improved treatment strategy is pivotal to improve its poor prognosis. Non-small cell lung cancer (NSCLC) is the predominant histological subtype of lung cancer. Gender-related discrepancies in overall survival and prognosis have been observed among NSCLC patients. This fact has ...

    • Progesterone receptors in prostate cancer: Progesterone receptor B is the isoform associated with disease progression 

      Grindstad, Thea K.W.; Richardsen, Elin; Andersen, Sigve; Skjefstad, Kaja Konstanse; Rakaee, Mehrdad; Dønnem, Tom; Ness, Nora; Nordby, Yngve; Bremnes, Roy M.; Al-Saad, Samer; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-27)
      The role of steroid hormones in carcinogenesis of the prostate is to some extent unraveled thorough the effect of androgen deprivation therapy on prostate cancer (PCa) progression. Other members of the steroid hormone family, such as progesterone, are also implicated in PCa, but progesterone’s role remains undefined. This study aimed to examine the distribution of progesterone receptor isoforms ...

    • Steroidhormoners rolle i kreftutvikling - et litteraturstudium 

      Skjefstad, Kaja Konstanse (Master thesis; Mastergradsoppgave, 2014-05-29)
      Sammenhengen mellom steroidhormoner og kreftutvikling har vært studert i flere tiår og det er velkjent at de kvinnelige kjønnshormonene østrogen og progesteron spiller viktige roller i utviklingen av hormonavhengige krefttyper som bryst-, ovarial- og livmorkreft. Likeledes er testosteron sin rolle i utviklingen av prostatakreft et felt som har blitt forsket, og fortsatt forskes, mye på. Hormonenes ...